Presentation description

To decipher the role of the MLLE and HECT domains in MCL, we will knockout the MLLE and HECT domains in MCL cell lines, JEKO1 and Mino cells by CRISPR/Cas9. Utilizing mass spectrometry techniques, we will define domain interactions and protein abundance changes specifically dependent on the MLLE and HECT domains. Using the information, we will form a better understanding of the role of UBR5 in MCL with the goal of providing insights to mantle cell lymphoma transformation and progression.