Presentation description

Currently, several tools exist for modeling membrane transport processes; however, none explicitly include the distinct influence of electrical and chemical gradients. Therefore, modeling systems whose transport behavior is affected by both membrane voltage and concentration gradients is limited. Herein, we report the continued development of a multiscale kinetic modeling framework that independently accounts for both forces in an electrochemical potential by constructing and solving a set of non-linear ordinary differential equations that include the spatial influence of the transmembrane voltage. We apply these methods to model the extreme acid response in E. coli, attempting to understand the role of the chloride-proton antiporter ClC-ec1.