Presentation description

This work is focused on the effects of conotoxins on homomeric Kv1.2 channels, and how beta subunits impact the biophysical properties of KV1.2. Mu3.1, a conotoxin isolated from Conus mucronatus, was tested on isolated Xenopus oocytes (expressing human Kv1.2). Using a two-electrode voltage clamp technique, we observed that Mu3.1 blocks the outward K-currents from homomeric Kv1.2 channels. To study K-channels, we use conotoxins (neuroactive peptides isolated from the venom of marine cone snails).

Group Member: Shannon Anderson